2019-11-13 · Salinomycin, which has been identified as a selective inhibitor of CSCs in multiple types of cancer, may be an attractive agent against CSCs thereby restrain hepatic metastasis in UM. The objective of the study is to explore the antitumor activity of salinomycin against UM and clarify its underlying mechanism.

Salinomycin sodium salt. Catalog # 3637. Datasheet / COA / SDS. Antibiotics Small Molecule. Discontinued Product. 3637 has been discontinued. View all

Salinomycin is as an antimicrobial and anticoccidial antibiotic. In 2009, a groundbreaking result was published in the scientific journal Cell (Ref), showing that Salinomycin can be effective in killing the cancer stem cells (CSC), the cancer cell population that is responsible for chemo resistance and metastasis. Salinomycin, traditionally used as an anti-coccidial drug, has recently been shown to possess anti-cancer and anti-cancer stem cell (CSC) effects, as well as activities to overcome multi-drug resistance based on studies using human cancer cell lines, xenograft mice, and in case reports involving cancer patients in pilot clinical trials. Salinomycin Premix Market Forecast to 2025 – Driven by Industry Major Players, Dynamics, Future Opportunities, Revenue, Growth By [email protected] on April 16, 2021 Detailed Study on the Global Salinomycin Premix Market SALINOMYCIN SODIUM. Salinomycin sodium salt. Salinomycin (sodium salt) UNII-92UOD3BMEK.

Salinomycin

It has been used in veterinary medicine as an antimicrobial against Gram negative bacteria and coccidioides. Salinomycin is as an antimicrobial and anticoccidial antibiotic. In 2009, a groundbreaking result was published in the scientific journal Cell (Ref), showing that Salinomycin can be effective in killing the cancer stem cells (CSC), the cancer cell population that is responsible for chemo resistance and metastasis. Salinomycin, traditionally used as an anti-coccidial drug, has recently been shown to possess anti-cancer and anti-cancer stem cell (CSC) effects, as well as activities to overcome multi-drug resistance based on studies using human cancer cell lines, xenograft mice, and in case reports involving cancer patients in pilot clinical trials.

Salinomycin Premix Market Forecast to 2025 – Driven by Industry Major Players, Dynamics, Future Opportunities, Revenue, Growth By [email protected] on April 16, 2021 Detailed Study on the Global Salinomycin Premix Market

Lund : Lund University, Faculty of Science, Department of Chemistry, Centre for Analysis and Synthesis, 2016. 69 p. Salinomycin is a polyether ionophore with broad spectrum Gram positive and anti-coccidial activity.

Salinomycin induces massive apoptosis in the multidrug-, radiation- and apoptosis-resistant human cancer cells. Salinomycin-induced apoptosis is independent of tumor suppressor protein p53, caspase activation, the CD95/CD95 ligand system, and the proteasome. Salinomycin fails to induce apoptosis in normal human peripheral CD4+ T lymphocytes.

Substance identity Substance identity. The ‘Substance identity’ section is calculated from substance identification information from all ECHA databases. 2 hours ago salinomycin/kg salinomycin sodium. — ≤ 10 g 20- desoxysalinomycin/kg salinomycin sodium.

Salinomycin (71; R = H), obtained by culturing a strain of Streptomyces albus 〈72JAP(K)7225392〉, and narasin (71; R = Me), 4-(S)-methylsalinomycin, the main component of a polyether complex produced by Streptomyces aurofaciens 〈78JAN1〉 are now used to prevent coccidiosis, particularly in broiler chickens. Salinomycin reduces the proportion of cancer stem cells(CSC) by >100-fold relative to paclitaxel, a commonly used breast cancer chemotherapeutic drug. Millipore Substance identity Substance identity. The ‘Substance identity’ section is calculated from substance identification information from all ECHA databases.

Get best price and read about company. Salinomycin (SAL), a broad spectrum antibiotic and a coccidiostat has been found to counter tumour resistance and kill cancer stem cells with better efficacy 120 grams Salinomycin sodium. Mechanism of Action: Salinocox® is an Ionophore coccidiostat that forms fat soluble complexes with Sodium and Potassium ions 21 Mar 2018 Sacox® microGranulates, containing salinomycin sodium (SAL-Na), for chickens for fattening and chickens reared for laying have been Salinomycin is an antibacterial and coccidiostat ionophore therapeutic drug.
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Salinomycin induces massive apoptosis in the multidrug-, radiation- and apoptosis-resistant human cancer cells. Salinomycin-induced apoptosis is independent of tumor suppressor protein p53, caspase activation, the CD95/CD95 ligand system, and the proteasome. Salinomycin fails to induce apoptosis in normal human peripheral CD4+ T lymphocytes.

Salinomycin (SAL), a broad spectrum antibiotic and a coccidiostat has been found to counter tumour resistance and kill cancer stem cells with better efficacy than the existing chemotherapeutic agents; paclitaxel and doxorubicin. This refocused its importance for treatment of human cancers. Salinomycin sodium | C42H69NaO11 | CID 23703990 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological 2017-03-28 · Salinomycin is a potent inhibitor of P-gp, which makes cells sensitive to chemotherapeutic drugs.

Salinomycin, traditionally used as an anti-coccidial drug, has recently been shown to possess anti-cancer and anti-cancer stem cell (CSC) effects, as well as activities to overcome multi-drug resistance based on studies using human cancer cell lines, xenograft mice, and in case reports involving cancer patients in pilot clinical trials.

3637 has been discontinued. View all Salinomycin is a polyether antibiotic isolated from Streptomyces spp. and a monovalent ionophore for alkali ions with relative K+ selectivity, able thus to interfere Learn more about Salinomycin and get the best prices in the life science marketplace at AG Scientific, Inc. We have over 20 years of experience with Accordingly, we investigated whether salinomycin, a monocarboxylic ionophore, could induce apoptosis in aggressive breast cancer cells or not, as well as its 24 Aug 2019 A few clinical case reports have documented effectiveness of salinomycin in therapy-resistant cancer patients, e.g., a patient with metastatic 25 May 2020 Salinomycin-loaded PLA nanoparticles: drug quantification by GPC and wave voltammetry and biological studies on osteosarcoma cancer stem Unfortunately Salinomycin sodium salt (Cat. No. ) has been withdrawn from sale for commercial reasons. 21 Mar 2018 Sacox® microGranulates, containing salinomycin sodium (SAL-Na), for chickens for fattening and chickens reared for laying have been Salinomycin can induce massive apoptosis in human cancer cells of different origin that display multiple mechanisms of drug and apoptosis resistance. Cell Data Salinomycin (Procoxacin) is an antibacterial and coccidiostat ionophore therapeutic agent. action of salinomycin.

Biosynthesis Salinomycin är en fodertillsats av gruppen koccidiostatika som ämnen avsedda att döda eller hindra tillväxten av parasitiska protozoer (encelliga organismer). Salinomycin in är endast tillåtet i vissa fjäderfäfoder och kan vara skadligt för andra djurslag. Salinomycin is an ionophore, also marketed as a coccidiostat, which is related more closely to monensin than is lasalocid. The ionic affinity of salinomycin is predominantly to sodium and potassium ions, and its mode of action and cellular effects are similar to those of monensin.87. Salinomycin, traditionally used as an anti-coccidial drug, has recently been shown to possess anti-cancer and anti-cancer stem cell (CSC) effects, as well as activities to overcome multi-drug resistance based on studies using human cancer cell lines, xenograft mice, and in case reports involving cancer patients in pilot clinical trials. Salinomycin (71; R = H), obtained by culturing a strain of Streptomyces albus 〈72JAP(K)7225392〉, and narasin (71; R = Me), 4-(S)-methylsalinomycin, the main component of a polyether complex produced by Streptomyces aurofaciens 〈78JAN1〉 are now used to prevent coccidiosis, particularly in broiler chickens. Salinomycin reduces the proportion of cancer stem cells(CSC) by >100-fold relative to paclitaxel, a commonly used breast cancer chemotherapeutic drug.